You may have a scenario where you do not want to give access to a Dynamics 365 instance to certain users. One way to do this is to use security groups in Office 365. To do this, create a security group and add administrators and members.
Then, in the Dynamics 365 Administration Center, select to edit your instance:

Scroll down to Security Group:

Select the security group you want to use:

Press Save and that’s it. Your instance will now be restricted.

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